EXPERIMENTAL PRODUCTION AND TRANSMISSION OF TAR SARCOMAS IN CHICKENS

Area of Science:

• Oncology
• Veterinary Pathology
• Carcinogenesis

Background:

• Spindle cell sarcomas are a type of soft tissue tumor.
• Embryomas are tumors containing disorganized tissues.
• Coal tar is a known carcinogen.

Purpose of the Study:

• To investigate the oncogenic potential of coal tar.
• To characterize the development and behavior of induced sarcomas in chickens.

Main Methods:

• Induction of embryomas in chickens.
• Injection of coal tar into induced embryomas.
• Serial transplantation of developed tumors.
• Attempts at transmission using tumor filtrate and desiccated material.

Main Results:

• Two cases of spindle cell sarcoma developed following coal tar injection.
• One induced sarcoma exhibited high invasiveness and spontaneous metastasis.
• This invasive tumor was successfully transplanted through eleven generations.
• Transmission of the neoplasm via filtrate or desiccated tumor was unsuccessful.

Conclusions:

• Coal tar can induce the development of invasive and metastatic spindle cell sarcomas in chickens.
• The causative agent of this neoplasm may not be transmissible by cell-free methods.
• Further research is needed to elucidate the etiology and transmission mechanisms of these induced tumors.