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Related Concept Videos

Vitamins01:30

Vitamins

Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced in our...
Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin, delayed...
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...

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Related Experiment Video

Updated: Jun 19, 2026

Encapsulation Thermogenic Preadipocytes for Transplantation into Adipose Tissue Depots
08:30

Encapsulation Thermogenic Preadipocytes for Transplantation into Adipose Tissue Depots

Published on: June 2, 2015

TISSUE CHANGES FOLLOWING DEPRIVATION OF FAT-SOLUBLE A VITAMIN.

S B Wolbach1, P R Howe

  • 1Department of Pathology, Harvard University Medical School, and the Forsyth Dental Infirmary, Boston.

The Journal of Experimental Medicine
|October 30, 2009
PubMed
Summary

Vitamin A deficiency causes epithelial tissues to be replaced by keratinizing epithelium, leading to loss of function but increased growth. This primary effect impacts various organs, potentially causing sterility and other health issues.

Related Experiment Videos

Last Updated: Jun 19, 2026

Encapsulation Thermogenic Preadipocytes for Transplantation into Adipose Tissue Depots
08:30

Encapsulation Thermogenic Preadipocytes for Transplantation into Adipose Tissue Depots

Published on: June 2, 2015

Area of Science:

  • Nutritional Science
  • Cell Biology
  • Pathology

Background:

  • Fat-soluble vitamin A is crucial for maintaining epithelial tissue integrity.
  • Deficiency leads to significant morphological changes in various organ systems.
  • Previous research has indicated a link between vitamin A and epithelial health.

Purpose of the Study:

  • To investigate the specific tissue changes resulting from fat-soluble vitamin A deprivation.
  • To elucidate the cellular mechanisms underlying epithelial alterations in vitamin A deficiency.
  • To explore the functional consequences of these morphological changes.

Main Methods:

  • Albino white rats were subjected to a diet deficient in fat-soluble vitamin A.
  • Morphological examination of epithelial tissues from various organs (respiratory, alimentary, eyes, genitourinary) was performed.
  • Cellular proliferation, mitotic activity, and nuclear changes were analyzed.

Main Results:

  • Vitamin A deficiency caused substitution of normal epithelium with stratified keratinizing epithelium in multiple tracts.
  • Epithelial replacement resulted from focal cell proliferation, not differentiation of existing cells.
  • While specific functions were lost, epithelial growth activity was augmented, with some neoplastic-like changes observed.

Conclusions:

  • Vitamin A deficiency primarily affects epithelial tissues, leading to functional loss and altered growth patterns.
  • The observed changes, including keratinization and potential neoplastic properties, are direct consequences of vitamin A withdrawal.
  • These findings have implications for understanding sterility and other pathologies associated with vitamin A deficiency.