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Related Experiment Video

Updated: Jun 19, 2026

Detection of Infectious Virus from Field-collected Mosquitoes by Vero Cell Culture Assay
07:23

Detection of Infectious Virus from Field-collected Mosquitoes by Vero Cell Culture Assay

Published on: June 9, 2011

A FILTER-PASSING VIRUS OBTAINED FROM DERMACENTOR ANDERSONI.

H Noguchi1

  • 1Laboratories of The Rockefeller Institute for Medical Research.

The Journal of Experimental Medicine
|October 30, 2009
PubMed
Summary

A novel virus isolated from Dermacentor andersoni ticks causes fever and enlarged spleen in guinea pigs. This tick-borne virus shows cross-immunity with spotted fever in guinea pigs.

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Area of Science:

  • Virology
  • Entomology
  • Pathogen Discovery

Background:

  • A filter-passing virus, pathogenic to guinea pigs, was isolated.
  • The virus was successfully cultivated on special media for at least seven generations.

Purpose of the Study:

  • To isolate and characterize a novel virus from Dermacentor andersoni ticks.
  • To investigate the pathogenicity and transmission of the isolated virus.

Main Methods:

  • Isolation of the virus from Dermacentor andersoni ticks.
  • Cultivation of the virus on special media.
  • Inoculation of guinea pigs, monkeys (Macacus rhesus), and rabbits.
  • Transmission studies involving infected guinea pigs and ticks.
  • Demonstration of virus presence in tick viscera.

Main Results:

  • The virus was pathogenic for guinea pigs, causing continuous high fever (104.5-106.5°F) and spleen enlargement.
  • Infection was established in one of two inoculated monkeys; rabbits showed negative results.
  • Virus transmission occurred from infected guinea pigs to ticks and from ticks to a guinea pig.
  • Guinea pigs surviving the febrile attack developed immunity to the cultured virus but remained susceptible to spotted fever virus, and vice versa.

Conclusions:

  • A novel, tick-borne virus pathogenic to guinea pigs has been identified.
  • The virus can be cultivated and transmitted via ticks, with distinct clinical signs in guinea pigs.
  • Cross-immunity observed suggests a relationship or distinction between this virus and spotted fever agents.

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