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Published on: February 14, 2017
THE RELATION OF THE RETICULO-ENDOTHELIAL SYSTEM TO THE BLOOD PLATELET COUNT
1Pathological Laboratories of the Brownsville and East New York Hospital, Brooklyn.
The Journal of Experimental Medicine
|October 30, 2009
Summary
Blocking the reticulo-endothelial system significantly elevates platelet counts. However, this increase is transient, indicating complex regulation beyond simple phagocytosis for platelet destruction.
Area of Science:
- Hematology
- Immunology
- Cell Biology
Background:
- The reticulo-endothelial system plays a role in platelet homeostasis.
- Platelet destruction mechanisms are not fully understood.
Purpose of the Study:
- To investigate the effect of reticulo-endothelial system blockade on platelet counts.
- To explore the mechanisms regulating platelet numbers.
Main Methods:
- Induction of reticulo-endothelial system blockade in experimental models.
- Monitoring of platelet counts over time.
Main Results:
- Blockade of the reticulo-endothelial system led to a significant and rapid increase in platelet count.
- Platelet counts showed a sharp partial recoil followed by a gradual decrease despite continued blockade.
- Evidence suggests that phagocytosis by reticulo-endothelial system cells is not the sole pathway for platelet destruction.
Conclusions:
- Platelet count regulation is complex and involves multiple mechanisms.
- Reticulo-endothelial system blockade provides insights into platelet kinetics and destruction pathways.
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