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¹Hospital of The Rockefeller Institute for Medical Research.

The Journal of Experimental Medicine

|October 30, 2009

Summary

This summary is machine-generated.

Researchers repeated experiments attempting to transform pneumococci into Streptococcus viridans using optochin. The resulting variant forms were identified as R-form pneumococci, not streptococci, based on bile solubility and immunological properties.

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Area of Science:

Microbiology
Bacteriology
Immunology

Background:

Morgenroth and collaborators reported transforming pneumococci into Streptococcus viridans using optochin.
This study investigates the nature of variant bacterial forms derived from pneumococci.

Purpose of the Study:

To repeat and verify Morgenroth's findings on pneumococci transformation.
To characterize the variant bacterial forms obtained through optochin treatment.

Main Methods:

Culturing pneumococci in optochin-containing media.
Characterizing variant strains based on bile solubility, autolysis, freeze-thaw sensitivity, and immunological reactions.
Attempting to replicate Morgenroth's rivanol-induced transformation of Streptococcus haemolyticus.

Main Results:

Variant forms derived from pneumococci were identified as R-form pneumococci, not Streptococcus viridans.
These R-form pneumococci exhibited distinct characteristics, including bile resistance and specific autolytic/immunological behaviors.
The study failed to replicate Morgenroth's rivanol-induced transformation of Streptococcus haemolyticus.

Conclusions:

The variant pneumococci obtained are R-form pneumococci, distinct from Streptococcus viridans.
The methods used by Morgenroth did not yield streptococci but rather modified pneumococcal strains.
Further investigation is needed to understand the discrepancies in transformation experiments.