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THE RELATION BETWEEN INVASION OF THE DIGESTIVE TRACT BY PARATYPHOID BACILLI AND DISEASE

T Smith1, H A Tibbetts

  • 1Department of Animal Pathology of The Rockefeller Institute for Medical Research, Princeton, N. J.

The Journal of Experimental Medicine
|October 30, 2009
PubMed

Insights

Hog cholera bacilli persist in the mouse ileum for weeks after ingestion and can invade organs. Mice have natural resistance, but large doses can overwhelm this, potentially causing disease.

Area of Science:

  • Veterinary Microbiology
  • Immunology

Background:

  • Hog cholera bacilli are a significant pathogen.
  • Understanding their fate in animal models is crucial for disease control.

Purpose of the Study:

  • To investigate the survival and dissemination of hog cholera bacilli in mice.
  • To determine the role of natural resistance in hog cholera pathogenesis.

Main Methods:

  • Oral and subcutaneous inoculation of mice with hog cholera bacilli.
  • Monitoring bacilli presence in the stomach, ileum, spleen, and other tissues over time.

Main Results:

  • Bacilli disappeared from the stomach within 24 hours but persisted in the ileum for weeks.
  • Bacilli penetrated the intestinal mucosa and were found in the spleen, sometimes for months.
  • Subcutaneous inoculation led to rapid intestinal tract colonization.
  • Mice exhibited natural resistance, which was overcome by large bacterial doses.

Conclusions:

  • Hog cholera bacilli can establish persistent infections in the ileum and disseminate to visceral organs in mice.
  • The dose of bacilli is critical in overcoming natural resistance and initiating disease.
  • Further research is needed to determine factors influencing mucosal invasion and disease development.

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