Related Experiment Video
Updated: Jun 19, 2026

Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance
Published on: July 21, 2023
STUDIES ON STREPTOCOCCUS BACTERIOPHAGE : II. THE INFLUENCE OF LYTIC PRINCIPLES UPON THE AGGLUTINATION OF HEMOLYTIC
1Laboratories of the Mount Sinai Hospital, New York.
Abstract:
A series of experiments was carried out on various strains of streptococci in order to ascertain the changes which bacteriophage produces in the phenomena of agglutination of these organisms. The results can be placed in the following categories. 1. Loss of specific agglutinability was observed with partial and with what appeared as complete loss of specific agglutinin absorption and agglutinogenic properties. 2. Partial modification of the antigen, bringing about inagglutinability of the strains with complete preservation of agglutinogenic and agglutinin-absorption properties. Coincidentally, additional components appeared. Some of these were related to the specific antigens of the organisms from which they were derived, while others were not. In two instances these components were of "group" character. 3. "Complete" modification observed with two strains consisting of complete transformation of the normal culture agglutinogens into antigens of an entirely different specificity. It appears from these studies that the bacteriophage phenomenon may play an intricate rô1e in serological grouping of various strains of pathogenic streptococci.
Related Concept Videos
Lytic Cycle of Bacteriophages
Viral Replication: Lysogenic Cycle
Lysogenic Cycle of Bacteriophages
Bacteriophages of the Human Virome
Viral Replication: Lytic Cycle
DNA Bacteriophages

