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Published on: March 13, 2012
THE USE OF HISTAMINE AS A STANDARD TEST FOR DIMINISHED RESISTANCE IN SUPRARENALECTOMIZED RATS
J Marmorston-Gottesman1, J Gottesman
1Division of Laboratories of Montefiore Hospital, New York.
The Journal of Experimental Medicine
|October 30, 2009
Abstract:
Of all the drugs thus far used in testing the resistance of suprarenalectomized rats, histamine has been found to be the most satisfactory. It is a readily obtainable and comparatively stable drug, producing characteristic symptoms. Its M.L.D. for a given strain of rats can be established within narrow limits, and the difference between the M.L.D. for normal and suprarenalectomized rats is comparatively great (1:20).

