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A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
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PHOTOSENSITIZATION OF ANIMALS AFTER THE INGESTION OF BUCKWHEAT.

C Sheard1, H D Caylor, C Schlotthauer

  • 1Section on Physics and Biophysical Research, the Section on Surgical Pathology, and the Division of Experimental Pathology and Surgery, Mayo Clinic and The Mayo Foundation, Rochester, Minnesota.

The Journal of Experimental Medicine
|October 30, 2009
PubMed
Summary
This summary is machine-generated.

Buckwheat ingestion causes photosensitization in guinea pigs, swine, and goats, with symptoms like itching and sloughing. The photodynamic substance responsible for this buckwheat photosensitivity may be phylloporphyrine.

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Area of Science:

  • Photobiology
  • Toxicology
  • Veterinary Dermatology

Background:

  • Photosensitization is a condition where skin becomes highly sensitive to light.
  • Certain plants are known to cause photosensitization in livestock, impacting animal health and agriculture.

Purpose of the Study:

  • To investigate the photosensitizing effects of buckwheat ingestion in various animal species.
  • To identify the specific wavelengths of light responsible for triggering photosensitivity reactions.
  • To explore the potential photodynamic substances involved in buckwheat-induced photosensitization.

Main Methods:

  • Administered buckwheat to guinea pigs, swine, goats, rabbits, dogs, mice, and rats.
  • Observed animals for signs of photosensitization and performed microscopic examinations.
  • Utilized quartz mercury vapor lamps and various filters to determine effective light wavelengths.
  • Conducted spectrophotometric analyses of buckwheat extracts and animal blood serums.

Main Results:

  • Guinea pigs, swine, and goats showed varying degrees of photosensitization, while rabbits, dogs, mice, and rats did not.
  • Symptoms included agitation, itching, urticaria, and sloughing, with evidence of profound toxemia.
  • Photosensitivity was linked to light wavelengths between 580 nm (yellow) and the red end of the spectrum.
  • Spectrophotometry revealed unique absorption bands in buckwheat extracts and serums of sensitized animals.
  • Phylloporphyrine is suggested as a potential photodynamic substance, excluding chlorophyll and hematoporphyrine.

Conclusions:

  • Buckwheat is a potent photosensitizer in certain animal species, causing significant toxic reactions.
  • The study identified the specific light spectrum triggering these reactions and proposed phylloporphyrine as the likely causative agent.
  • Findings contribute to understanding plant-induced photosensitization and inform preventative strategies in animal husbandry.