Related Experiment Videos
Differential development of angiotensin II receptor subtypes in the rat brain
1Section on Pharmacology, National Institute of Mental Health, Bethesda, MD 20892.
Endocrinology
|January 1, 1991
Abstract:
Angiotensin II receptors in selected brain areas were characterized into two distinct subtypes by displacement with specific antagonists. The receptor subtypes had different developmental patterns. Type-1 receptors, selectively displaced by the specific angiotensin antagonist DuP-753, were predominant in adult (8-weeks-old) rats. Type-2 receptors were selectively displaced by CGP 42112 A and were expressed remarkably in young (2-weeks-old) rats.