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Vector Competence Analyses on Aedes aegypti Mosquitoes using Zika Virus
Published on: May 31, 2020
THE INCUBATION PERIOD OF YELLOW FEVER IN THE MOSQUITO
1Laboratories of the Commission on Yellow Fever, International Health Division of the Rockefeller Foundation, Lagos, Nigeria, West Africa.
The Journal of Experimental Medicine
|October 30, 2009
Summary
Yellow fever virus infects Aedes aegypti mosquitoes and is transmitted via their bite starting around the 9th day. Infected mosquitoes cause typical yellow fever pathology in rhesus monkeys.
Area of Science:
- Virology
- Entomology
- Infectious Diseases
Background:
- Yellow fever is a severe hemorrhagic disease transmitted by mosquitoes.
- Understanding the extrinsic incubation period (EIP) of yellow fever virus in mosquitoes is crucial for vector control.
Purpose of the Study:
- To determine the infectious period of yellow fever virus within Aedes aegypti mosquitoes.
- To establish the time frame for virus transmission by infected mosquitoes.
Main Methods:
- Mosquitoes (Aedes aegypti) were fed on animals infected with yellow fever virus.
- Infectivity of mosquitoes was assessed daily by injecting mosquito homogenates into rhesus monkeys.
- Transmission efficiency was evaluated through mosquito bites on susceptible monkeys.
Main Results:
- Infectious yellow fever virus was present in Aedes aegypti throughout the extrinsic incubation period.
- Mosquito transmission occurred on or after the 9th day post-infection.
- Inoculation of monkeys with infected mosquitoes produced typical yellow fever pathology.
Conclusions:
- Aedes aegypti mosquitoes remain infectious for yellow fever virus throughout the EIP.
- Mosquito bite transmission is established by the 9th-12th day after initial infection.
- Experimental yellow fever in monkeys is reliably induced by infected mosquito material.
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