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Updated: Jun 19, 2026

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
Published on: September 12, 2016
SUPPRESSION OF THE FIRST ATTACK WITH SUBSEQUENT RELAPSE: AN IMMUNE PHENOMENON IN EXPERIMENTAL RELAPSING FEVER
1Department of Medicine, Peking Union Medical College, Peking, China, and the Department of Preventive Medicine and Public Health, Vanderbilt University, Nashville, Tennessee.
Abstract:
In five splenectomized squirrels and chipmunks which were reinoculated with a strain of Spironema recurrentis which had previously been present in their blood, the first attack was entirely suppressed because the animals were immune to the strain of spirochetes inoculated; but after the interval which usually occurred between attacks, a relapse ensued, in which the strain of spirochetes present in the blood was different from the strain inoculated.
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