STUDIES OF THE LYMPHATIC TISSUE : III. EXPERIMENTAL STUDIES OF THE RELATION OF THE LYMPHATIC TISSUE TO THE NUMBER OF
1Hospital of The Rockefeller Institute for Medical Research.
Abstract:
1. On subcutaneous infection of rabbits with staphylococci of low virulence there appears at the place of injection first a hemorrhagicpurulent inflammation and later a localized purulence. In the regional lymph nodes there is lymphatic hyperplasia, and in the blood a lymphocytosis. 2. In the regional lymph nodes there is first a regressive change of Flemming's secondary nodules and of transition forms. Then follows lymphatic hyperplasia, starting apparently from solid secondary nodules and progressing by way of pseudo-secondary nodules to a diffuse lymphoid hyperplasia. The increase of lymphocytes in the blood parallels this development. 3. Only after the highest point of the lymphocytosis has been reached or passed do we find the first Flemming's secondary nodules, which thereafter increase in number and size while the number of lymphocytes in the blood falls, and reach their maximum development when the number of lymphocytes in the blood is again normal. Therefore, the original conception of Flemming that the site of formation of the lymphocytes of the blood is in Flemming's secondary nodules, cannot be accepted. 4. The lymphocytes of the blood originate in the pseudo-secondary nodules as in embryonic life. The mother cells of the lymphocytes would appear to be Marchand's proliferating endothelial (reticular) cells.
Related Concept Videos
01:18Lymphoid Cells and Tissues
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
01:23Detailed Structure and Function of Lymph Nodes
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
01:28Functions of the Lymphatic and Immune System
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
01:23Introduction to Lymphatic and Immune System
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are born...
01:15Development of the Lymphatic System
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
01:16Lymphatic Vessels and Lymph Transport
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular spaces.