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Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia

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OUTLYING ACIDOSIS DUE TO FUNCTIONAL ISCHEMIA.

P Rous¹, D R Drury

¹Laboratories of The Rockefeller Institute for Medical Research.

The Journal of Experimental Medicine

|October 30, 2009

Summary

Tissue acidity can develop independently of blood pH changes during vasoconstriction. This localized tissue acidosis occurs in peripheral tissues, particularly during conditions of reduced blood volume or pressure.

Area of Science:

Physiology
Biochemistry

Background:

Peripheral vasoconstriction can lead to tissue acidity.
This acidity may occur independently of changes in blood pH, with blood potentially becoming more alkaline.
Localized tissue acidosis has been observed in peripheral tissues under various functional conditions.

Purpose of the Study:

To investigate the relationship between peripheral vasoconstriction and tissue acidity.
To determine if tissue acidosis is always associated with blood pH changes.
To characterize the distribution and conditions under which tissue acidosis develops.

Main Methods:

Observational study of tissue pH changes during functional conditions.
Analysis of blood pH in conjunction with tissue pH.
Induction of varying degrees of blood volume depletion (hemorrhage, anhydremia) and observation of resultant tissue acidosis.

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Main Results:

Tissue acidosis was frequently observed independently of blood pH changes.
Patchy tissue acidosis in superficial connective tissue and skeletal muscles correlated with local ischemia due to compensatory vasoconstriction.
Generalized superficial tissue acidosis occurred with extreme depletion.
No such acidoses were found in visceral tissues.

Conclusions:

Tissue acidosis can develop in peripheral areas, independent of blood pH.
Localized ischemia resulting from compensatory vasoconstriction is a key factor in patchy tissue acidosis.
The extent of tissue acidosis is related to the severity of depletion and local conditions.