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Detection of Foodborne Bacterial Pathogens from Individual Filth Flies

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ETIOLOGY OF OROYA FEVER : XIV. THE INSECT VECTORS OF CARRION'S DISEASE.

H Noguchi¹, R C Shannon, E B Tilden

¹The Rockefeller Institute for Medical Research, and the International Health Division of the Rockefeller Foundation, New York.

The Journal of Experimental Medicine

|October 30, 2009

Summary

This study identified phlebotomi sandflies as vectors for Carrion's disease in Peru. Researchers found Bartonella bacilliformis in phlebotomi, which transmitted the bacteria to monkeys, confirming their role in spreading Oroya fever and verruga peruana.

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Area of Science:

Medical Entomology
Infectious Diseases
Parasitology

Background:

Carrion's disease, prevalent in Peru, has an unknown mode of transmission.
Bartonella bacilliformis is the causative agent of Oroya fever and verruga peruana.

Purpose of the Study:

To determine the insect vectors responsible for transmitting Carrion's disease in Peru.
To investigate the role of blood-sucking insects in the transmission of Bartonella bacilliformis.

Main Methods:

Collection and transportation of various blood-sucking insects from endemic Peruvian districts.
Intradermal inoculation of crushed insects into rhesus monkeys.
Monitoring monkey blood cultures and observing for lesion development post-inoculation.

Main Results:

Bartonella bacilliformis was detected exclusively in phlebotomi (sandflies).
Monkeys inoculated with phlebotomi yielded cultures of Bartonella bacilliformis, causing characteristic lesions.
Infection with phlebotomi-derived strains conferred immunity against human strains, and vice versa.

Conclusions:

Certain phlebotomi species act as insect vectors for Carrion's disease (Oroya fever and verruga peruana).
Phlebotomus noguchii is identified as a definite vector; Phlebotomus verrucarum is a probable vector.
Phlebotomus peruensis's role as a vector remains uncertain.