Related Experiment Video
Updated: Jun 19, 2026
09:09
Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock
Published on: November 3, 2023
THE BLOOD IN HOG CHOLERA.
1Department of Animal Pathology of The Rockefeller Institute for Medical Research, Princeton, N. J.
The Journal of Experimental Medicine
|October 30, 2009
Summary
Researchers could not identify the hog cholera virus in swine blood. However, blood analysis revealed progressive anemia and severe leucopenia, aiding in differential diagnosis.
Area of Science:
- Veterinary Pathology
- Hematology
- Virology
Background:
- Hog cholera is a significant swine disease.
- The etiological agent of hog cholera has not been definitively identified through blood examination or culture.
- Understanding blood changes is crucial for diagnosis.
Purpose of the Study:
- To systematically examine blood from swine with hog cholera.
- To identify any formed elements associated with the hog cholera virus.
- To characterize quantitative blood changes during hog cholera infection.
Main Methods:
- Prolonged and systematic examination of swine blood.
- Blood cultures were performed.
- Quantitative analysis of blood components, including anemia and leucopenia.
- In vitro incubation of hog cholera blood with different anticoagulants (heparin, potassium oxalate, sodium citrate).
- Comparison with leucocytic reactions in other swine diseases and conditions.
Main Results:
- No formed element identifiable as the hog cholera virus was found in blood.
- Blood cultures for the virus were unsuccessful.
- Hog cholera is characterized by progressive anemia and severe leucopenia, affecting polymorphonuclear and lymphocytic cells.
- In vitro incubation with heparin exacerbated leucopenia; other anticoagulants showed no significant effect.
- Leucocyte counts show potential for differential diagnosis.
Conclusions:
- The hog cholera virus remains elusive in blood.
- Quantitative blood changes, particularly leucopenia, are characteristic of hog cholera.
- Leucocyte counts may serve as a valuable tool in the differential diagnosis of hog cholera in swine.
Related Concept Videos
01:25Cholera
Cholera is an acute gastrointestinal disease caused by the Gram-negative bacterium Vibrio cholerae. It is transmitted primarily via the fecal-oral route through the ingestion of contaminated water or food.Vibrio cholerae is a motile, Gram-negative bacterium of the family Vibrionaceae, primarily associated with waterborne outbreaks in areas with inadequate sanitation. Although over 200 serogroups of V. cholerae exist, only O1 and O139 are responsible for epidemic cholera. The O1 serogroup,...
01:30Reservoir of Infection
Infectious diseases arise from intricate interactions between pathogens and their reservoirs. A reservoir of infection refers to the natural habitat where a pathogen lives, grows, and multiplies, serving as a continual source of infection. Reservoirs are broadly classified as either living or nonliving, and each plays a unique role in disease transmission, significantly influencing public health interventions and control strategies.Humans act as reservoirs for a wide array of pathogens,...
01:18Bacterial Gastroenteritis
Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
02:45Blood Transfusion and Agglutination
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...