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EXPERIMENTS WITH THE VIRUS OF POLIOMYELITIS

R Thompson1

  • 1Department of Bacteriology, College of Physicians and Surgeons, Columbia University, New York.

The Journal of Experimental Medicine
|October 30, 2009
PubMed
Summary

Researchers found that the poliomyelitis virus cannot be adapted to rabbits, with no evidence of disease or immunity development. Attempts to infect monkeys also failed, indicating limited susceptibility in these animal models.

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Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...