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Bioluminescence Imaging to Detect Late Stage Infection of African Trypanosomiasis

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Published on: May 18, 2016

THE BLOOD CHEMISTRY OF AN ACUTE TRYPANOSOME INFECTION.

¹Department of Bacteriology, College of Physicians and Surgeons, Columbia University, New York.

The Journal of Experimental Medicine

|October 30, 2009

Summary

Infection with Trypanosoma equiperdum significantly alters serum CO(2) capacity and increases blood lecithin. Liver glycogen depletes, while kidney function declines in later stages.

Area of Science:

Biochemistry
Veterinary Parasitology
Pathology

Background:

Trypanosoma equiperdum causes significant physiological disturbances.
Understanding metabolic changes during infection is crucial for treatment.

Purpose of the Study:

To investigate the biochemical and pathological changes in rats infected with Trypanosoma equiperdum.
To characterize the impact of infection on serum, blood, liver, and kidney parameters.

Main Methods:

Analysis of serum CO(2) capacity.
Quantification of non-protein nitrogen, uric acid, cholesterol, and lecithin in blood.
Assessment of liver glycogen levels.
Histopathological examination of kidneys.

Main Results:

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Serum CO(2) capacity decreased early in infection.
Blood lecithin markedly increased (20-50%).
Liver glycogen was reduced early and absent late in infection.
Non-protein nitrogen and uric acid increased in terminal stages.
Kidneys showed degenerative changes; cholesterol remained unchanged.

Conclusions:

Trypanosoma equiperdum infection induces profound metabolic alterations.
Lecithin increase and glycogen depletion are key biochemical markers.
Kidney pathology indicates severe systemic impact.