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THE DISTRIBUTION OF FRIEDLANDER'S BACILLI OF DIFFERENT TYPES

L A Julianelle1

  • 1Hospital of The Rockefeller Institute for Medical Research.

The Journal of Experimental Medicine
|October 30, 2009
PubMed

Insights

Friedländer

Area of Science:

  • Microbiology
  • Bacteriology

Background:

  • Friedländer's bacillus is a significant pathogen.
  • Understanding its distribution and characteristics is crucial for disease control.

Purpose of the Study:

  • To classify strains of Friedländer's bacillus based on serological types.
  • To investigate the correlation between serological types and clinical sources.
  • To analyze sugar fermentation patterns and their diagnostic utility.

Main Methods:

  • Serological typing of 80 Friedländer's bacillus strains.
  • Analysis of strain sources (human, animal, various diseases).
  • Sugar fermentation tests for all strains.
  • Precipitin reaction test using urine from a pneumonia patient.

Main Results:

  • Distribution: 52% Type A, 15% Type B, 9% Type C, 24% Group X.
  • Type A strains predominantly linked to human diseases, especially pneumonia (>70%).
  • Type B strains more common in animal sources; Group X strains from diverse diseases.
  • A specific precipitin reaction was observed in urine from a Type A pneumonia patient.
  • No correlation found between serological type and fermentation activity.
  • Fermentation reactions are variable and unreliable for differentiating closely related organisms.
  • Group X strains exhibited the most fermentation variability.
  • 13 of 15 lactose-negative strains belonged to Type A.

Conclusions:

  • Friedländer's bacillus exhibits distinct serological types with varying clinical associations.
  • Serological typing, particularly Type A with pneumonia, shows diagnostic potential.
  • Sugar fermentation is not a reliable method for classifying Friedländer's bacillus strains.
  • Further research into specific precipitin reactions may aid in rapid diagnosis.

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