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A Human Fallopian Tube Model for Investigation of C. trachomatis Infections
Published on: August 11, 2012
THE EFFECT OF SECONDARY INFECTIONS ON EXPERIMENTAL TRACHOMA
P K Olitsky1, R E Knutti, J R Tyler
1Laboratories of The Rockefeller Institute for Medical Research.
The Journal of Experimental Medicine
|October 30, 2009
Summary
Secondary bacterial infections in trachoma models can mimic florid human trachoma. Introducing common bacteria alongside Bacterium granulosis in monkeys with existing lesions produced trachoma-like symptoms.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Microbiology
Background:
- Trachoma's later stages are theorized to involve secondary infections.
- Previous research indicated common conjunctival bacteria alone cause minimal reactions.
Purpose of the Study:
- To investigate if secondary bacterial infections influence trachoma manifestation in animal models.
- To replicate florid human trachoma (Type IIb and c) in experimental animals.
Main Methods:
- Implantation of common bacteria onto conjunctivae of monkeys with existing granulosis lesions.
- Utilized bacteria found in conjunctival sacs of humans and monkeys.
- Controlled experiments with Bacterium granulosis and control animals.
Main Results:
- Experimental animals developed a condition resembling florid human trachoma.
- Observed increased hyperemia, edema, thickening, and papillary hypertrophy.
- Microscopic analysis revealed increased scar tissue, lymphoid infiltration, and papillary hyperplasia.
Conclusions:
- Secondary bacterial inoculation can alter the presentation of trachoma in animal models.
- The induced condition closely mimics the florid stage of human trachoma.
- Findings support the role of secondary infections in trachoma pathogenesis.
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