Related Experiment Video
Updated: Jun 19, 2026
08:07
Equine Enteric Glial Culture and Application to the Study of a Neural Inflammatory Mechanism in Equine Colic
Published on: October 4, 2024
VIBRIONIC ENTERITIS IN CALVES
1Department of Animal Pathology of The Rockefeller Institute for Medical Research, Princeton, N. J.
The Journal of Experimental Medicine
|October 30, 2009
Summary
This study identifies Vibrios as the cause of a calf intestinal disorder. Experimental infections confirmed Vibrios cause inflammation, progressing from mild to severe in calves.
Area of Science:
- Veterinary Medicine
- Microbiology
- Animal Pathology
Background:
- A specific intestinal disorder affects calves, typically observed in those over two weeks old.
- The disease's severity increases with chronicity, involving more of the small intestine.
Purpose of the Study:
- To identify the causative agent of a calf intestinal disorder.
- To investigate the pathogenesis and experimental reproduction of the disease.
Main Methods:
- Isolation and cultivation of Vibrios from naturally infected calves (acute and chronic cases).
- Experimental inoculation of a calf with a Vibrio strain.
- Passage of the Vibrio strain through calves to assess pathogenicity.
Main Results:
- Vibrios were consistently isolated from inflamed intestinal mucosa in spontaneous cases.
- Experimental infection with Vibrios led to subclinical and severe intestinal inflammation.
- Vibrios were also detected in the liver in some spontaneous cases.
Conclusions:
- Vibrios are identified as the causative agent of this calf intestinal disorder.
- The severity of the disease is linked to the chronicity and experimental passage of the Vibrio infection.
Related Concept Videos
01:18Bacterial Gastroenteritis
Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
01:18Viral Meningitis
Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
01:22Bacterial Meningitis I: Introduction
Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
01:24Bacterial Meningitis
Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...
01:26Encephalitis ll: Pathophysiology
Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
01:23Stringent Response in E. coli
Bacterial growth is closely tied to nutrient availability, with cells proliferating exponentially under favorable conditions and entering a stationary phase when resources become scarce. This transition is mediated by a regulatory mechanism known as the stringent response, which allows bacteria to adapt to nutrient deprivation by modulating gene expression and metabolic activity.During nutrient scarcity, intracellular amino acid levels decline. It results in the accumulation of uncharged tRNAs...