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COMPARISON OF THE REDUCING POWER OF SOME TYPICAL TRANSPLANTABLE TUMORS AND OF TUMORS PRODUCED BY FILTERABLE VIRUSES :
1Lasker Foundation for Medical Research and the Department of Medicine, The University of Chicago, Chicago.
Abstract:
1. The tissues of Rous chicken sarcoma and of the infectious myxoma of the rabbit do not possess the oxidation-reduction enzyme succinodehydrogenase, which is present in normal tissues and in transplantable tumors. 2. Filterable virus diseases (rabbit Virus III, rabbit neurovaccine, rabbit herpes, fowl-pox) produce in the tissues affected by them a partial inhibition of succinodehydrogenase.
Insights
Rous chicken sarcoma and infectious myxoma tissues lack succinodehydrogenase. Viral diseases partially inhibit this enzyme in affected tissues, impacting cellular respiration.
Area of Science:
- Biochemistry
- Oncology
- Virology
Background:
- Succinate dehydrogenase (SDH) is a key enzyme in cellular respiration.
- Normal tissues and transplantable tumors typically exhibit SDH activity.
- Certain viral infections and cancers may alter metabolic enzyme function.
Purpose of the Study:
- To investigate the presence and activity of succinate dehydrogenase (SDH) in Rous chicken sarcoma and infectious myxoma.
- To determine the effect of filterable virus diseases on SDH activity in affected tissues.
Main Methods:
- Histochemical analysis of tissues for succinate dehydrogenase activity.
- Comparative study of enzyme levels in normal, tumor, and virus-infected tissues.
Main Results:
- Rous chicken sarcoma and infectious myxoma tissues showed a complete absence of succinate dehydrogenase.
- Filterable viral diseases including rabbit Virus III, neurovaccine, herpes, and fowl-pox induced partial inhibition of succinate dehydrogenase in affected tissues.
Conclusions:
- The absence of succinate dehydrogenase in Rous chicken sarcoma and infectious myxoma suggests a metabolic alteration in these disease states.
- Viral infections can significantly impair cellular respiration by inhibiting key enzymes like succinate dehydrogenase.
