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Related Concept Videos

Acute Inflammation III: Local and Systemic Effects01:25

Acute Inflammation III: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the exudate's...
Inflammation01:38

Inflammation

Overview
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
Acute Inflammation II: Cellular Phase01:26

Acute Inflammation II: Cellular Phase

The cellular phase of acute inflammation is a tightly orchestrated sequence of events that recruits leukocytes, primarily neutrophils, to sites of tissue injury or infection. Following the initial vascular changes, this phase ensures effective immune cell migration, activation, and function at the affected site to eliminate pathogens and initiate tissue repair.Leukocyte Recruitment CascadeLeukocyte recruitment happens in four steps: margination, adhesion, transmigration, and chemotaxis. Reduced...

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Related Experiment Video

Updated: Jun 19, 2026

Measurement of Cytosolic Ca2+ in Isolated Contractile Lymphatics
08:08

Measurement of Cytosolic Ca2+ in Isolated Contractile Lymphatics

Published on: December 8, 2011

LYMPH PRESSURES IN STERILE INFLAMMATION.

M E Field1, C K Drinker, J C White

  • 1Department of Physiology, Harvard School of Public Health, Boston.

The Journal of Experimental Medicine
|October 30, 2009
PubMed
Summary

Normal lymph pressure in dog legs is unmeasurable. Sterile inflammation elevates lymph pressure to 120 cm, mirroring venous pressure changes, and heat affects lymph dynamics.

Area of Science:

  • Physiology
  • Lymphatic System Dynamics

Background:

  • Lymphatic system function is crucial for fluid balance and immune response.
  • Understanding lymph pressure variations is key to diagnosing and treating edemas and inflammatory conditions.

Purpose of the Study:

  • To investigate normal and inflammation-induced lymph pressure in canine legs.
  • To determine the relationship between venous pressure and lymph pressure during inflammation.
  • To explore the effects of thermal stress on lymphatic parameters.

Main Methods:

  • Utilized anesthetized dogs for physiological measurements.
  • Induced sterile inflammation to simulate pathological conditions.
  • Measured lymph pressure, venous pressure, lymph flow, and lymph protein concentration under varying thermal conditions.

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A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation

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Last Updated: Jun 19, 2026

Measurement of Cytosolic Ca2+ in Isolated Contractile Lymphatics
08:08

Measurement of Cytosolic Ca2+ in Isolated Contractile Lymphatics

Published on: December 8, 2011

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice
05:59

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice

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A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation
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Main Results:

  • Normal lymph pressure in quiescent canine legs was not measurable.
  • Sterile inflammation led to a maximum lymph pressure of approximately 120 cm of lymph.
  • Elevated venous pressure during inflammation was followed by a rise in lymph pressure.
  • Exposure to temperatures between 50-60°C altered lymph flow, pressure, and protein concentration.

Conclusions:

  • Lymphatic pressure regulation is significantly influenced by venous pressure during inflammation.
  • Thermal stress impacts multiple facets of lymphatic function, including flow, pressure, and composition.
  • These findings provide baseline data for further research into lymphatic disorders and therapeutic interventions.