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Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...

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Adjuvant Activity of Mycobacterium paratuberculosis in Enhancing the Immunogenicity of Autoantigens During Experimental Autoimmune Encephalomyelitis

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ACTIVE IMMUNIZATION AGAINST POLIOMYELITIS.

M Brodie¹

¹Department of Bacteriology, McGill University, Montreal, Canada.

The Journal of Experimental Medicine

|October 30, 2009

Summary

This summary is machine-generated.

A single low-dose poliovirus inoculation creates significant immunity. Virus-serum combinations also provide immunity, but excess serum reduces the immune response in animals.

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Adjuvant Activity of Mycobacterium paratuberculosis in Enhancing the Immunogenicity of Autoantigens During Experimental Autoimmune Encephalomyelitis

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Particle Agglutination Method for Poliovirus Identification

Particle Agglutination Method for Poliovirus Identification

Published on: April 20, 2011

Area of Science:

Virology
Immunology
Infectious Diseases

Background:

Poliomyelitis is a serious viral disease.
Understanding immunity to poliovirus is crucial for prevention.

Purpose of the Study:

To investigate the immunogenicity of subinfective poliovirus doses.
To evaluate the impact of virus-serum combinations on poliovirus immunity.

Main Methods:

Intracutaneous inoculation of animals with subinfective poliovirus doses.
Administration of varying concentrations of virus-serum combinations.

Main Results:

Subinfective poliovirus inoculation induced substantial immunity.
Virus-serum combinations conferred immunity when serum levels were adequate.
Excessive serum in virus-serum combinations diminished the immune response.

Conclusions:

Subinfective poliovirus inoculation is an effective method for generating immunity.
Careful titration of serum is necessary for effective virus-serum combination therapy against poliovirus.