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A TRANSMISSIBLE TUMOR-LIKE CONDITION IN RABBITS.

¹Department of Animal and Plant Pathology of The Rockefeller Institute for Medical Research, Princeton, N. J.

The Journal of Experimental Medicine

|October 30, 2009

Summary

A novel tumor-like condition in cottontail rabbits is transmissible to other rabbits but not to rodents or chickens. This fibroma-like tumor presents distinct clinical and pathological features in affected animals.

Area of Science:

Veterinary Pathology
Oncology
Wildlife Disease

Background:

A spontaneous tumor-like condition was identified in a wild cottontail rabbit.
The condition exhibited characteristics resembling a fibroma.

Purpose of the Study:

To investigate the transmissibility of the observed tumor-like condition.
To describe the clinical and pathological features of the induced tumors.

Main Methods:

Experimental inoculation of the transmissible agent into wild and domestic rabbits.
Inoculation attempts into guinea pigs, white rats, white mice, and chickens.
Clinical and pathological examination of induced lesions.

Main Results:

The condition was successfully transmitted to both wild and domestic rabbits.

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Transmission was unsuccessful in guinea pigs, white rats, white mice, and chickens.

The experimentally produced tumors shared pathological similarities with the original fibroma-like lesion.

Conclusions:

The observed tumor-like condition in cottontail rabbits is a transmissible fibroma.
The agent demonstrates host specificity, affecting rabbits but not other tested species.
Further research into the etiology and transmission routes of this rabbit fibroma is warranted.