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Updated: Jun 19, 2026

A Detailed Protocol for Characterizing the Murine C1498 Cell Line and its Associated Leukemia Mouse Model
Published on: October 14, 2016
STUDIES ON MOUSE LEUKEMIA : VII. THE RELATION OF CELL DEATH TO THE POTENCY OF INOCULATED CELL SUSPENSIONS
1Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, and the Department of Genetics, Carnegie Institution of Washington, Cold Spring Harbor.
Abstract:
The effect of heat, hypo- and hypertonic salt solutions, glycerin, desiccation, and mechanical injury was studied on leukemic lymphoid cells of the mouse, and the leukemia-transmitting property of cell suspensions (hypothetical transmitting agent) in vitro. The results indicate that leukemia has not been transmitted by inoculation without the introduction of living cells. The interval between inoculation and death bears an inverse relationship to the number of living cells inoculated.

