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Related Experiment Video

Updated: Jun 19, 2026

Measuring Local Anaphylaxis in Mice

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

ANAPHYLACTIC SHOCK BY AZODYES.

K Landsteiner¹, J van der Scheer

¹Laboratories of The Rockefeller Institute for Medical Research.

The Journal of Experimental Medicine

|October 30, 2009

Summary

This summary is machine-generated.

Anaphylactic shock was induced in sensitized animals using specific azodyes. These reactions were highly specific, even with minimal dye amounts, demonstrating a targeted immune response.

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Published on: September 14, 2018

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Last Updated: Jun 19, 2026

Measuring Local Anaphylaxis in Mice

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Published on: September 14, 2018

Area of Science:

Immunology
Allergy research
Pharmacology

Background:

Anaphylaxis is a severe allergic reaction.
Azoproteins and azodyes are chemical compounds with potential allergenic properties.

Purpose of the Study:

To investigate the induction of anaphylactic shock using azodyes in sensitized animals.
To determine the specificity and sensitivity of anaphylactic reactions to azodyes.

Main Methods:

Sensitization of animals with azoproteins.
Induction of anaphylactic shock by injecting specific azodyes.
Observation and quantification of anaphylactic reactions.

Main Results:

Anaphylactic shock was successfully induced in animals sensitized with azoproteins.
The induced reactions were specific to the azo components of the antigen.
Anaphylaxis occurred with very small quantities of azodyes (milligrams).

Conclusions:

Azodyes can effectively induce anaphylactic shock in specifically sensitized animals.
The anaphylactic response to azodyes is highly specific.
This study highlights the potential of azodyes as allergens and provides a model for studying allergic reactions.