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EXPERIMENTS ON THE CONVERSION OF TYPHUS STRAINS.

H Mooser1, G Varela, H Pilz

  • 1Laboratory of the American Hospital, Mexico City, and the Institute of Hygiene, Popotla, Mexico.

The Journal of Experimental Medicine
|October 30, 2009
PubMed
Summary
This summary is machine-generated.

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Murine typhus and epidemic typhus strains are not distinct. A novel method converts epidemic strains into murine strains, suggesting both originate from murine sources.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Epidemiology

Background:

  • Typhus fever presents as murine and epidemic types in Mexico.
  • Epidemic strains can resemble historic Old World typhus strains.
  • Intermediate strains have been isolated from epidemics.

Purpose of the Study:

  • To investigate the relationship between murine and epidemic typhus strains.
  • To develop a method for converting epidemic typhus strains into murine strains.
  • To determine the origin of typhus virus strains.

Main Methods:

  • Daily blood injections into intraperitoneally inoculated rats were used.
  • This method leverages the multiplication of Rickettsia prowazeki in cells with frequent blood contact.
  • Experimental conversion of epidemic non-orchitic strains to murine strains was performed.

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Main Results:

  • Epidemic strains were successfully converted into murine strains, causing scrotal lesions in guinea pigs and fatal disease in rats.
  • This conversion was also achieved with an Old World epidemic typhus strain.
  • The experimental manipulation demonstrated the plasticity of typhus strains.

Conclusions:

  • There is no fundamental difference between Old World and New World typhus viruses.
  • Both typhus types are considered to be of murine origin.
  • Murine strains represent the original form, while epidemic strains result from human-to-human transmission cycles.