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Establishment and Validation of a Rat Model of Pulmonary Arterial Hypertension Associated with Pulmonary Fibrosis
Published on: May 23, 2025
THE PULMONARY ARTERIAL PRESSURE IN NORMAL ALBINO RATS AND THE EFFECT THEREON OF EPINEPHRINE
1Department of Physiology, Harvard School of Public Health, and the Department of Pathology, Harvard Medical School, Boston.
The Journal of Experimental Medicine
|October 30, 2009
Abstract:
1. A satisfactory method for the direct determination of the pulmonary arterial pressure in rats is described. 2. The arithmetical mean of the blood pressure in the pulmonary artery in a series of thirty-four normal albino rats under nembutal anesthesia is 256 mm. H(2)0 (18.8 mm. Hg). 3. Intravenous epinephrine causes an abrupt but briefly sustained rise in the pulmonary arterial pressure with a gradual return to normal.
