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EXPERIMENTAL TYPE III PNEUMOCOCCUS PNEUMONIA IN MONKEYS : I. PRODUCTION AND CLINICAL COURSE

T Francis1, E E Terrell

  • 1Hospital of The Rockefeller Institute for Medical Research.

The Journal of Experimental Medicine
|October 30, 2009
PubMed

Insights

Researchers created an experimental pneumonia in cynomolgus monkeys using Type III Pneumococcus. This model closely mimics human pneumococcus lobar pneumonia, offering insights into disease progression and outcomes.

Area of Science:

  • * Infectious Diseases
  • * Pulmonology
  • * Veterinary Pathology

Background:

  • * Pneumococcus lobar pneumonia is a significant human respiratory illness.
  • * Animal models are crucial for understanding disease pathogenesis and testing interventions.
  • * Previous models may not fully replicate the clinical and pathological features of human disease.

Purpose of the Study:

  • * To establish and characterize an experimental model of pneumococcus lobar pneumonia in cynomolgus monkeys.
  • * To investigate the clinical and pathological manifestations of induced pneumonia.
  • * To identify potential indicators of disease severity and outcome.

Main Methods:

  • * Intratracheal and intrabronchial inoculation of Type III Pneumococcus in *M. cynomolgos* monkeys.
  • * Clinical observation of disease progression, including fever and general condition.
  • * Pathological examination of pulmonary lesions and assessment of septicemia.

Main Results:

  • * Successfully induced experimental pneumonia resembling human lobar pneumonia.
  • * Observed localized lobar pulmonary lesions, septicemia, and sustained fever.
  • * Noted significant variations in disease severity attributed to individual animal resistance.
  • * Bacteremia levels correlated with disease outcome, serving as a key prognostic indicator.

Conclusions:

  • * The experimental pneumonia model in cynomolgus monkeys accurately reflects key aspects of human pneumococcus lobar pneumonia.
  • * Individual host resistance is a critical factor influencing disease severity.
  • * Septicemia levels provide a valuable objective measure for predicting the outcome of experimental pneumococcal pneumonia.

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