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LOUPING ILL IN MAN

T M Rivers1, F F Schwentker

  • 1Hospital of The Rockefeller Institute for Medical Research.

The Journal of Experimental Medicine
|October 30, 2009
PubMed

Insights

This study describes four human infections consistent with louping ill. Neutralization tests suggest antibodies found in patients likely resulted from exposure to the louping ill virus.

Area of Science:

  • Veterinary Medicine
  • Virology
  • Infectious Diseases

Background:

  • Louping ill is a tick-borne viral disease primarily affecting sheep.
  • Human infections are rare but can occur through exposure to infected ticks or animals.

Purpose of the Study:

  • To document and analyze human cases suspected of louping ill.
  • To investigate the serological evidence of louping ill virus infection in humans.

Main Methods:

  • Clinical case descriptions of four human infections.
  • Serological analysis using neutralization tests on patient sera.
  • Epidemiological data collection on circumstances of exposure.

Main Results:

  • Four human cases exhibited symptoms and epidemiological links suggestive of louping ill.
  • Neutralization tests detected antibodies against the louping ill virus in the sera of affected individuals.
  • Antibody presence strongly indicates recent infection or significant exposure to the virus.

Conclusions:

  • The findings support the occurrence of louping ill in humans.
  • Serological evidence confirms the etiological role of the louping ill virus in these cases.
  • Highlights the potential for zoonotic transmission and the importance of diagnostic confirmation.

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