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Poliomyelitis

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...

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Updated: Jun 19, 2026

Purification of High Yield Extracellular Vesicle Preparations Away from Virus

Purification of High Yield Extracellular Vesicle Preparations Away from Virus

Published on: September 12, 2019

ULTRAFILTRATION OF THE VIRUS OF POLIOMYELITIS.

M Theiler¹, J H Bauer

¹Laboratories of the International Health Division of the Rockefeller Foundation, New York.

The Journal of Experimental Medicine

|October 30, 2009

Summary

This summary is machine-generated.

The size of the human poliovirus was estimated between 12 and 17 micrometers using ultrafiltration. Technical challenges suggest the actual virus size may be even smaller, requiring further investigation.

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Purification of High Yield Extracellular Vesicle Preparations Away from Virus

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Area of Science:

Virology
Biophysics

Background:

Poliomyelitis is a severe infectious disease caused by the poliovirus.
Accurate sizing of viruses is crucial for understanding their structure and behavior.

Purpose of the Study:

To estimate the size of the human poliovirus.
To explore the utility of ultrafiltration for viral size determination.

Main Methods:

Ultrafiltration analysis was employed to determine viral size.
The study involved analyzing the passage of human poliovirus through filters of varying pore sizes.

Main Results:

The estimated size of the human poliovirus ranged between 12 and 17 micrometers (µm).
Technical difficulties and low viral concentration indicated potential for a smaller actual size.

Conclusions:

Ultrafiltration provides an estimate for human poliovirus size.
Further research is needed to refine size estimation due to experimental limitations.