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I. BARTONELLA INCIDENCE IN SPLENECTOMIZED BILE FISTULA DOGS
1Department of Pathology, School of Medicine and Dentistry, The University of Rochester, Rochester, N. Y.
The Journal of Experimental Medicine
|October 30, 2009
Summary
Splenectomized dogs with bile fistulas experienced anemia linked to Bartonella canis. Treatment with Neosalvarsan showed a sterilizing effect, while spleen extract inhibited anemia and bile pigment overproduction.
Area of Science:
- Veterinary Medicine
- Infectious Diseases
- Hematology
Background:
- Splenectomized dogs with bile fistulas spontaneously develop anemia.
- This anemia is linked to excessive bile pigment production.
- Bartonella canis-like bodies were observed in the blood during these anemic periods.
Purpose of the Study:
- To investigate the cause of spontaneous anemia in splenectomized bile fistula dogs.
- To determine the role of Bartonella canis in the observed anemia.
- To evaluate potential treatments for the condition.
Main Methods:
- Observation of spontaneous anemia in splenectomized bile fistula dogs.
- Inoculation of Bartonella-containing blood into splenectomized dogs.
- Administration of Neosalvarsan and spleen extract.
- Morphological examination of blood for Bartonella bodies.
Main Results:
- Anemia and excessive bile pigment production occurred in splenectomized bile fistula dogs.
- Three out of four dogs showed Bartonella canis-like bodies during anemic periods.
- Inoculation of Bartonella bodies into splenectomized dogs induced blood destruction.
- Neosalvarsan demonstrated a sterilizing effect, and spleen extract inhibited anemia.
Conclusions:
- Bartonella canis infection is implicated in the anemia of splenectomized bile fistula dogs.
- Neosalvarsan is a potential treatment for this condition.
- Spleen extract may help manage anemia and bile pigment overproduction.
