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Analysis of Iophenoxic Acid Analogues in Small Indian Mongoose (Herpestes Auropunctatus) Sera for Use as an Oral Rabies Vaccination Biological Marker

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RABBIT POX : REPORT OF AN EPIDEMIC.

P D Rosahn¹, C K Hu

¹Laboratories of The Rockefeller Institute for Medical Research.

The Journal of Experimental Medicine

|October 30, 2009

Summary

Rabbit pox outbreaks reveal transmission via personal carriers during incubation. Recovered rabbits show sustained immunity for 9-12 months, with young from immune mothers exhibiting increased resistance.

Area of Science:

Veterinary Pathology
Infectious Diseases
Immunology

Background:

An isolated animal room experienced a rabbit pox epidemic during the winter of 1933-34.
The current epidemic shared similarities with a previous pox outbreak in the preceding year.

Purpose of the Study:

To report observations on a rabbit pox epidemic.
To compare clinical and pathological findings with a previous outbreak.
To investigate transmission routes and etiological agent relatedness.

Main Methods:

Clinical observation of affected rabbits.
Pathological examination of tissues.
Immunological comparison of etiological agents.
Assessment of immunity duration and maternal antibody effects.

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Main Results:

Clinical signs included generalized papular eruption, blepharitis, ophthalmia, nasal discharge, and lymphadenopathy.
Pathological findings showed epidermal vacuolization, necrosis, and vesicle formation, differing from the previous year's dermal-confined pathology.
Evidence supported transmission via personal carriers, even before diagnosis, and demonstrated immunological relatedness of the causative agents.
Immunity persisted for 9-12 months post-recovery.
Offspring of immune does showed greater refractoriness to pox lesions.

Conclusions:

Rabbit pox can be transmitted by personal carriers during the incubation period.
The etiological agents from both outbreaks were immunologically related, inducing long-lasting immunity.
Maternal immunity confers protection to young rabbits against pox lesions.