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MENINGITIS IN MAN CAUSED BY A FILTERABLE VIRUS : II. IDENTIFICATION OF THE ETIOLOGICAL AGENT

T M Rivers1, T F Scott

  • 1Hospital of The Rockefeller Institute for Medical Research.

The Journal of Experimental Medicine
|October 30, 2009
PubMed

Insights

This study identifies an active agent as a virus, demonstrating its immunological identity with known lymphocytic choriomeningitis viruses. The research explores its natural host and implications for human diseases.

Area of Science:

  • Virology
  • Immunology
  • Infectious Diseases

Background:

  • The nature of an active infectious agent was under investigation.
  • Previous research on lymphocytic choriomeningitis (LCM) viruses by Armstrong, Lillie, and Traub provided a basis for comparison.

Purpose of the Study:

  • To identify an active agent as a virus.
  • To characterize the agent's reactions in laboratory animals.
  • To determine the agent's immunological identity and its natural host, and to assess its significance in human diseases.

Main Methods:

  • Experimental inoculation of laboratory animals with the active agent.
  • Comparative analysis of the agent's properties against known viruses.
  • Immunological assays to establish identity with lymphocytic choriomeningitis viruses.

Main Results:

  • The active agent was confirmed to be a virus.
  • Reactions in laboratory animals were documented.
  • Immunological identity was established between the studied virus and Armstrong and Lillie's LCM virus, as well as Traub's virus.
  • Evidence regarding the natural host and potential role in human diseases was presented.

Conclusions:

  • The active agent is a virus immunologically identical to known LCM viruses.
  • The virus has a natural host and potential implications for human health.
  • Further investigation into its role in human diseases is warranted.

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