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Updated: Jun 19, 2026
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
AN EPIDEMIC IN A MOUSE COLONY DUE TO THE VIRUS OF ACUTE LYMPHOCYTIC CHORIOMENINGITIS
1Department of Animal and Plant Pathology of The Rockefeller Institute for Medical Research, Princeton, N. J.
Abstract:
A filtrable virus, identical with that which causes acute lymphocytic choriomeningitis, has been found to cause a disease in white mice. Naturally infected mice usually show no symptoms, but such animals inoculated intracerebrally with sterile bouillon or other materials develop characteristic symptoms. The same symptoms are produced by intracerebral injection of the virus into mice from a disease-free stock. Guinea pigs are very susceptible and are therefore useful for detecting the virus and for neutralization tests. The disease in both naturally infected and inoculated animals is discussed and the pathological findings given.
Insights
A filtrable virus causing lymphocytic choriomeningitis also causes disease in mice. Guinea pigs are highly susceptible, aiding virus detection and neutralization tests for this viral disease.
Area of Science:
- Virology
- Infectious Diseases
- Animal Models
Background:
- A filtrable virus linked to lymphocytic choriomeningitis has been identified.
- Naturally infected mice often remain asymptomatic.
Purpose of the Study:
- To investigate the viral disease caused by the lymphocytic choriomeningitis virus in mice.
- To establish the utility of guinea pigs in studying this viral infection.
Main Methods:
- Intracerebral inoculation of mice with the virus.
- Observation of clinical signs and pathological findings in infected mice.
- Utilizing guinea pigs for virus detection and neutralization assays.
Main Results:
- Intracerebral inoculation induced characteristic symptoms in mice, even in those from disease-free stocks.
- Guinea pigs demonstrated high susceptibility, proving valuable for diagnostic purposes.
- Pathological findings in naturally infected and inoculated animals were documented.
Conclusions:
- The virus responsible for lymphocytic choriomeningitis induces a distinct disease in mice.
- Guinea pigs serve as a sensitive model for detecting and neutralizing this specific virus.
- Understanding the disease and pathology in animal models is crucial for viral research.
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