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AN UNSATURATED FATTY ACID FRACTION OF PIG PANCREAS WHICH INHIBITS THE GROWTH OF CHICKEN SARCOMA
1Lilly Laboratories for Clinical Research, Indianapolis City Hospital, and the Lilly Research Laboratories, Indianapolis.
The Journal of Experimental Medicine
|October 30, 2009
Summary
Unsaturated fatty acids from pancreatic tissue inhibit chicken sarcoma growth. Oleic acid, similar to these fatty acids, also demonstrated growth-inhibiting properties in comparable quantities.
Area of Science:
- Biochemistry
- Oncology
- Veterinary Medicine
Background:
- Pancreatic tissue exhibits inhibitory properties against certain biological agents.
- Chicken Tumor I is a known oncogenic agent in avian models.
Purpose of the Study:
- To identify the specific component in pancreatic tissue responsible for its observed inhibitory action.
- To evaluate the efficacy of unsaturated fatty acids, particularly oleic acid, in inhibiting chicken sarcoma growth.
Main Methods:
- Extraction and fractionation of pancreatic tissue components.
- Assay of inhibitory activity against the chicken sarcoma agent using aqueous extracts.
- Characterization of fatty acid properties via acid and iodine number determination.
Main Results:
- The inhibitory action was localized to the unsaturated fatty acid fraction of pancreatic tissue.
- As little as 0.1 mg of unsaturated fatty acid inhibited the chicken sarcoma agent.
- Commercial oleic acid showed similar inhibitory effects on chicken sarcoma growth in comparable amounts.
Conclusions:
- Unsaturated fatty acids, including oleic acid, possess significant inhibitory activity against the chicken sarcoma agent.
- These findings suggest a potential therapeutic role for specific fatty acids in managing certain oncogenic conditions.