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Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

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Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
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Related Experiment Video

Updated: Jun 19, 2026

Measuring Local Anaphylaxis in Mice
07:49

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

ANAPHYLACTIC SENSITIZATION WITH CHEMICALLY DEFINITE COMPOUNDS.

H E Fierz1, W Jadassohn, W Stoll

  • 1Chemical Laboratory, Federal Polytechnic Institute, and the Dermatological Clinic of the University of Zurich, Zurich, Switzerland.

The Journal of Experimental Medicine
|October 30, 2009
PubMed
Summary
This summary is machine-generated.

Sodium atoxyl-diazoamino-sulfoanthranilate injection in guinea pigs induces anaphylactic hypersensitivity. The compound likely decomposes and forms an azoprotein in vivo, causing sensitization.

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Area of Science:

  • Immunology
  • Pharmacology
  • Biochemistry

Background:

  • Anaphylaxis is a severe allergic reaction.
  • Azoproteins can induce hypersensitivity.
  • The in vivo formation of sensitizing agents is not fully understood.

Purpose of the Study:

  • To investigate the mechanism of sensitization by sodium atoxyl-diazoamino-sulfoanthranilate.
  • To determine if the injected compound or its in vivo metabolite is responsible for hypersensitivity.

Main Methods:

  • Guinea pigs were injected with sodium atoxyl-diazoamino-sulfoanthranilate.
  • Anaphylactic hypersensitiveness was assessed using the Schultz-Dale test.

Main Results:

  • Injection induced anaphylactic hypersensitiveness to the corresponding azoprotein.
  • The Schultz-Dale test confirmed the hypersensitivity.

Conclusions:

  • Sodium atoxyl-diazoamino-sulfoanthranilate likely decomposes in vivo.
  • The compound couples with body proteins to form an azoprotein.
  • This in vivo-formed azoprotein is responsible for sensitizing the organism.