Related Experiment Video

Updated: Jun 19, 2026

Transsynaptic Tracing from Peripheral Targets with Pseudorabies Virus Followed by Cholera Toxin and Biotinylated Dextran Amines Double Labeling
13:12

Transsynaptic Tracing from Peripheral Targets with Pseudorabies Virus Followed by Cholera Toxin and Biotinylated Dextran Amines Double Labeling

Published on: September 14, 2015

REINFECTION (SECOND ATTACK) IN EXPERIMENTAL POLIOMYELITIS

S Flexner1

  • 1Laboratories of The Rockefeller Institute for Medical Research.

The Journal of Experimental Medicine
|October 30, 2009
PubMed

Insights

Monkeys reinfected with poliomyelitis virus can experience second attacks, even after recovery from initial infections. This suggests reinfection is possible regardless of prior disease severity or immunization status.

Area of Science:

  • Virology
  • Immunology
  • Infectious Diseases

Background:

  • Poliomyelitis is a serious infectious disease.
  • Understanding reinfection dynamics is crucial for disease control.

Purpose of the Study:

  • To investigate the susceptibility of recovered monkeys to poliomyelitis reinfection.
  • To determine if prior infection severity or hyperimmunization affects reinfection.

Main Methods:

  • Experimental poliomyelitis induction in monkeys.
  • Re-inoculation with homologous and heterologous poliovirus strains.
  • Observation of disease progression following second inoculation.

Main Results:

  • Recovered monkeys are susceptible to reinfection via the nasal route.
  • Reinfection occurs with both the original and different poliovirus strains.
  • Monkeys with mild, severe, or hyperimmunized convalescent states can be reinfected.
  • The proposed 2-year period to distinguish relapses from second attacks may be too long.

Conclusions:

  • Poliomyelitis reinfection is possible in recovered monkeys.
  • Prior infection severity and hyperimmunization do not prevent reinfection.
  • Further research on human poliomyelitis reinfection is needed for definitive conclusions.

More Related Videos

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness12:21

A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness

Published on: September 28, 2022

Related Concept Videos

Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Immunological Memory01:23

Immunological Memory

Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature is...
Viral Recombination00:57

Viral Recombination

Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
Smallpox01:24

Smallpox

Smallpox is a severe contagious disease caused by the Variola major virus, a double-stranded DNA member of the Poxviridae family.Variola major transmission occurs primarily via inhalation of virus-laden droplets or direct contact with infectious scabs. The incubation period averages approximately seven days, although it may range from 7 to 17 days depending on the inoculum and host factors.Clinically, the prodromal phase is marked by an abrupt onset of high fever, malaise, headache, and myalgia.
Rabies01:28

Rabies

Rabies is a lethal zoonotic disease caused by a single-stranded, negative-sense RNA virus of the Lyssavirus genus, within the family Rhabdoviridae. Its primary mode of transmission to humans is through bites or saliva-contaminated scratches from infected mammals such as dogs, bats, raccoons, or foxes. Transmission can also occur if infectious saliva contacts abraded skin or intact mucous membranes, including the conjunctiva.Viral Entry and Early ReplicationOnce introduced at the bite or scratch...
Vaccinations01:51

Vaccinations

Overview