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Particle Agglutination Method for Poliovirus Identification
Published on: April 20, 2011
VIRUSES OF POLIOMYELITIS : AN IMMUNOLOGICAL COMPARISON OF SIX STRAINS.
J D Trask1, J R Paul, A R Beebe
1Departments of Pediatrics, Medicine and Surgery, Yale University School of Medicine, and the New Haven Hospital and Dispensary, New Haven.
Qualitative immunological differences were found in poliovirus strains. These variations correlate with the geographic and temporal origins of the poliomyelitis virus epidemics.
Area of Science:
- Immunology
- Virology
- Epidemiology
Background:
- Poliomyelitis virus strains can exhibit distinct immunological characteristics.
- Early passage or 'human' strains are of particular interest for understanding viral evolution.
Purpose of the Study:
- To investigate qualitative immunological differences among poliovirus strains.
- To determine if these differences relate to the epidemic source of the virus.
Main Methods:
- Analysis of 4 poliovirus strains.
- Isolation of strains from different years during eastern and western epidemics.
- Qualitative immunological characterization.
Main Results:
- Significant qualitative immunological variations were identified between the studied poliovirus strains.
- These immunological differences demonstrated a correlation with the epidemic source, distinguishing between eastern and western epidemic origins.
Conclusions:
- Early passage poliovirus strains possess distinct immunological profiles.
- The immunological characteristics of poliovirus strains are linked to their epidemiological source, reflecting geographic and temporal variations in circulation.
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