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Updated: Jun 19, 2026

Measurement of Heme Synthesis Levels in Mammalian Cells
Published on: July 9, 2015
DOES LIVER SUPPLY FACTORS IN ADDITION TO IRON AND COPPER FOR HEMOGLOBIN REGENERATION IN NUTRITIONAL ANEMIA?
E B Hart1, C A Elvehjem, G O Kohler
1Department of Agricultural Chemistry, University of Wisconsin, Madison.
Abstract:
1. Our data indicate that the effectiveness of whole liver in the treatment of nutritional anemia in rats induced by a milk diet is directly proportional to its available iron and copper content. The other constituents in liver are not needed for maximum hemoglobin regeneration on a diet of milk, iron, copper, and manganese. 2. Commercial preparations of liver products with iron or iron and copper vary greatly in their hemoglobin-regenerating efficiency in rats with nutritional anemia. The variation is correlated directly with the iron and copper content of the preparation. When the copper-iron ratio was too wide hemoglobin regeneration was checked, although the iron supply was sufficient for optimum regeneration.
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