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Updated: Jun 19, 2026

A Fluorescence-based Method to Study Bacterial Gene Regulation in Infected Tissues
Published on: February 19, 2019
ON THE MODE OF ACTION OF SULFANILAMIDE IN EXPERIMENTAL STREPTOCOCCUS EMPYEMA
1Department of Bacteriology, College of Physicians and Surgeons, Columbia University, New York.
Sulfanilamide effectively treats streptococcus empyema in rabbits by inhibiting bacterial growth and aiding immune cell response. This study highlights the drug
Area of Science:
- Bacteriology
- Immunology
- Pharmacology
Background:
- Streptococcus empyema is a fatal condition.
- Sulfanilamide is an early antibacterial drug.
Purpose of the Study:
- To investigate the efficacy of sulfanilamide in treating experimental streptococcus empyema in rabbits.
- To elucidate the mechanism of action of sulfanilamide in vivo.
Main Methods:
- Rabbits were inoculated with Streptococcus.
- Sulfanilamide was administered subcutaneously.
- Histological examination of pleural exudate and tissues was performed.
Main Results:
- Sulfanilamide prevented mortality and sterilized the infected cavity.
- In vitro studies showed inhibition of Streptococcus by treated animal fluids but not complete sterilization.
- Histology revealed increased clasmatocyte and leukocyte accumulation in treated animals.
Conclusions:
- Sulfanilamide achieves therapeutic effect through bacteriostasis, supporting host immune defenses.
- Local immune cells, particularly clasmatocytes, are crucial for complete bacterial clearance.
- The drug enhances the natural immune response rather than directly killing bacteria.
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