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Related Concept Videos

Inflammation01:38

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Autoregulation of Blood Flow01:17

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Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
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Related Experiment Video

Updated: Jun 19, 2026

An in vivo Assay to Test Blood Vessel Permeability
07:03

An in vivo Assay to Test Blood Vessel Permeability

Published on: March 16, 2013

CHANGES IN BLOOD VESSELS (CAPILLARY FRAGILITY) WITH INFLAMMATION.

E Zander1

  • 1Department of Pathology, Cornell University Medical College and New York Hospital, New York.

The Journal of Experimental Medicine
|October 30, 2009
PubMed
Summary
This summary is machine-generated.

Inflammation alters skin blood vessel resistance to suction-induced bleeding. Initially, resistance increases, followed by decreased vascular integrity, leading to enhanced capillary fragility and hemorrhage. Allergic inflammation accelerates these changes.

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Non-invasive Assessment of Microvascular and Endothelial Function
05:41

Non-invasive Assessment of Microvascular and Endothelial Function

Published on: January 29, 2013

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Last Updated: Jun 19, 2026

An in vivo Assay to Test Blood Vessel Permeability
07:03

An in vivo Assay to Test Blood Vessel Permeability

Published on: March 16, 2013

Non-invasive Assessment of Microvascular and Endothelial Function
05:41

Non-invasive Assessment of Microvascular and Endothelial Function

Published on: January 29, 2013

Area of Science:

  • Vascular biology
  • Dermatology
  • Immunology

Background:

  • Suction applied to rabbit skin causes intracutaneous hemorrhage.
  • Inflammation induced by various agents alters the skin's response to suction.
  • Understanding these changes is crucial for studying vascular integrity.

Purpose of the Study:

  • To investigate the effects of inflammation on skin vascular resistance to suction.
  • To characterize the temporal changes in capillary fragility following inflammatory stimuli.
  • To explore the role of inflammation in conditions like the Shwartzman phenomenon.

Main Methods:

  • Application of partial vacuum suction (-70 mm. Hg) to rabbit skin.
  • Induction of inflammation using diverse agents (turpentine, bacterial components, filtrates).
  • Measurement of time to hemorrhage under suction at various time points post-inflammation.

Main Results:

  • Normal skin hemorrhages in ~8 minutes; inflammation initially increases resistance (30 min-2 hrs).
  • Following initial resistance, capillary fragility increases, causing hemorrhage in 1-4 minutes (12-24 hrs post-injection).
  • Capillary fragility duration varies (2-9 days or longer) depending on the inflammatory agent and sensitization.

Conclusions:

  • Inflammation significantly alters skin vascular resistance and capillary fragility.
  • Allergic inflammation can accelerate and intensify these vascular changes.
  • These findings provide insights into vascular injury mechanisms, relevant to phenomena like Shwartzman.