Related Experiment Video
Updated: Jun 19, 2026

Studying the Activity of Neuropeptides and Other Regulators of the Excretory System in the Adult Mosquito
Published on: August 24, 2021
THE ABSENCE FROM THE URINE OF PERNICIOUS ANEMIA PATIENTS OF A MOSQUITO GROWTH FACTOR PRESENT IN NORMAL URINE
W Trager1, D K Miller, C P Rhoads
1Department of Animal and Plant Pathology, The Rockefeller Institute for Medical Research, Princeton, New Jersey, and the Hospital of The Rockefeller Institute for Medical Research, New York.
Abstract:
Extracts prepared from the urine of normal persons or patients with aplastic anemia or leukemia contain a substance, possibly flavine or a flavine compound, which under suitable conditions of test enhances the growth of larvae of the mosquito, Aëdes aegypti. This substance is lacking, or is present in much smaller amount, in extracts from the urine of pernicious anemia patients showing symptoms of the disease. Extracts from the urine of the same patients after adequate treatment contain as much of the substance as normal urine extracts.
Related Concept Videos
Urine Studies I: Urinalysis
Malaria
Physiology of Urine Formation
Glomerular Filtration
The first stage in urine formation is glomerular filtration. Each kidney contains approximately 1 million nephrons, the functional units of filtration, with a...
Symbiosis
Microbiota of the Urogenital Tract

