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Updated: Jun 19, 2026

Expression and Purification of Virus-like Particles for Vaccination
Published on: June 2, 2016
A SOLUBLE ANTIGEN OF LYMPHOCYTIC CHORIOMENINGITIS : I. SEPARATION OF SOLUBLE ANTIGEN FROM VIRUS
J E Smadel1, R D Baird, M J Wall
1Hospital of The Rockefeller Institute for Medical Research.
Abstract:
The virus of lymphocytic choriomeningitis can be sedimented in the ultracentrifuge and washed repeatedly; the virus retains its activity provided that a small amount of normal serum is present in the diluent. A soluble substance capable of fixing complement in the presence of immune serum can be separated from the virus. Washed virus fixes complement poorly. The serologically specific soluble antigen is widely distributed in tissues of infected guinea pigs, mice, and monkeys.
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