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Updated: Jun 19, 2026

Isolation and Intravenous Injection of Murine Bone Marrow Derived Monocytes

Isolation and Intravenous Injection of Murine Bone Marrow Derived Monocytes

Published on: December 27, 2014

ENCEPHALOPATHY FOLLOWING INJECTIONS OF BONE MARROW EXTRACT.

¹Department of Animal and Plant Pathology of The Rockefeller Institute for Medical Research, Princeton, New Jersey.

The Journal of Experimental Medicine

|October 30, 2009

Summary

Monkey bone marrow extract causes a unique brain condition (encephalopathy) in animals, damaging Purkinje cells and blood vessels. This research explores the pathogenesis and similarities to viral diseases.

Area of Science:

Neuroscience
Pathology
Toxicology

Background:

Intracerebral injection of monkey bone marrow extract induces neurological damage in experimental animals.
The observed condition is characterized by specific cellular and vascular pathologies.

Purpose of the Study:

To investigate the pathological effects of monkey bone marrow extract on the central nervous system.
To characterize the resulting encephalopathy and compare it to other neurological conditions.

Main Methods:

Intracerebral administration of monkey bone marrow extract to guinea pigs and rabbits.
Histopathological examination of brain tissue, focusing on Purkinje cells, glia, and cerebral vasculature.

Main Results:

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Severe Purkinje cell damage, particularly in the cerebellum, with intranuclear inclusion bodies.

Hyaline necrosis of cerebral blood vessels and secondary cerebellar softening.

Similar pathological changes observed with extracts from Hodgkin's disease lymph nodes and human leucocytic cream.

Conclusions:

The extract induces a non-inflammatory encephalopathy, distinct from encephalitis.
Pathogenesis involves glial reactions and vascular damage, with potential links to viral disease mechanisms.