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Updated: Jun 19, 2026

Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model
Published on: June 18, 2013
PERMEABILITY OF THE HUMAN PLACENTA TO ANTIBODIES : A QUANTITATIVE STUDY
1Serological and Bacteriological Laboratory of the Office of the Chief Medical Examiner, and the Bellevue Hospital Out-Patient Department Laboratory of the Department of Hospitals of New York City, New York.
Abstract:
The ratio of the titers of various antibodies, namely, hemagglutinins and syphilitic reagin, in the maternal blood to that of the corresponding antibody in the cord blood was found to be relatively constant, falling somewhere between 8 and 16. This figure may be considered the "index of permeability" of human placenta to antibodies, or the coefficient of distribution of antibodies between maternal and cord blood. The possible application of these findings to the study of the placental permeability to sensitizing antibodies (or reagins) is discussed.
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