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Related Experiment Video

Updated: Jun 19, 2026

Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites

Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites

Published on: May 18, 2016

PASSIVE IMMUNITY IN AVIAN MALARIA.

R D Manwell¹, F Goldstein

¹Department of Zoology, Syracuse University, Syracuse, New York.

The Journal of Experimental Medicine

|October 30, 2009

Summary

This summary is machine-generated.

Immune serum therapy can confer passive immunity against Plasmodium circumflexum avian malaria. Therapeutic serum effectiveness is enhanced by superinfection, with pre-infection administration showing greater efficacy.

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Area of Science:

Veterinary Parasitology
Immunology
Avian Medicine

Background:

Avian malaria, caused by Plasmodium species, poses a significant threat to bird health.
Understanding passive immunity mechanisms is crucial for developing effective treatments.
Plasmodium circumflexum is a specific avian malaria parasite relevant to this study.

Purpose of the Study:

To investigate the efficacy of immune serum therapy in treating Plasmodium circumflexum infections in birds.
To determine the potential for passive immunity transfer in avian malaria.
To explore factors influencing the effectiveness of serum therapy, such as superinfection and timing of administration.

Main Methods:

Thirty-two cases of Plasmodium circumflexum infection induced by blood inoculation were studied.
Therapeutic serum was sourced from chronic cases, with elevated immune titres achieved through superinfection.
Control groups received normal serum or physiological saline for comparison.

Main Results:

Eighteen cases receiving immune serum showed no parasites; seven exhibited milder infections compared to controls.
Immune serum therapy, particularly when administered before infection, demonstrated significant therapeutic effects.
Superinfection increased the concentration of protective substances in therapeutic serum.
Observed agglutination of parasitized cells with immune serum suggests immune interaction.

Conclusions:

Passive immunity can be successfully conferred in avian malaria using immune serum against Plasmodium circumflexum.
The concentration of protective serum factors can be enhanced via superinfection, though their specificity requires further investigation.
Serum therapy is more effective when administered prophylactically (before infection) rather than therapeutically (after infection).