Related Experiment Video
Updated: Jun 19, 2026

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
Published on: August 25, 2021
PROPERTIES OF THE CAUSATIVE AGENT OF A CHICKEN TUMOR : XIV. RELATION BETWEEN A TUMOR NUCLEOPROTEIN AND THE ACTIVE
Abstract:
1. The tumor-producing fraction, isolated from Chicken Tumor I by means of differential centrifugation at high speed, has been investigated as regards its power to absorb ultraviolet light. A characteristic absorption spectrum was found, with a maximum at lambda2575. The absorbing power of the material in that region was largely due to the presence of nucleic acid, or of a closely related compound. 2. Inactivation of the purified tumor fraction with ultraviolet light depressed the absorbing power of the material, especially in the region of 2600-2500A. These changes were those which nucleic acid would present under the same conditions. 3. Inactivation of the tumor agent with acid or alkali was accompanied by decomposition of the tumor nucleoprotein and passage of free nucleic acid into solution. 4. Partial or complete inactivation of the tumor agent by heat, at 50 degrees or 65deg;C., was attended by liberation of nucleic acid of low molecular weight. 5. The parallelism between tumor-producing activity and the integrity of the tumor ribonucleoprotein suggests that the nucleoprotein may be an essential part of the active principle.
Related Concept Videos
Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Mutagenicity and Carcinogenicity
Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer
Mechanisms of Retrovirus-induced Cancers

