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Updated: Jun 19, 2026

Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes
Published on: June 28, 2024
CHOLINE AS A MEMBER OF THE VITAMIN B(2) COMPLEX
1Babies and Childrens Hospital, the Institute of Pathology, and the Departments of Pediatrics and Pathology, School of Medicine, Western Reserve University, Cleveland.
Abstract:
The experimental rations commonly used in studies on the vitamin B(2) complex are, as a rule, low in content of choline. Addition of vitamin B(6) has an aggravating influence on the specific effect of deficiency of choline, especially with regard to the development of cortical necrosis of the kidneys. The acute and subacute lesions associated with this specific type of renal injury are described. The renal lesions and fat infiltration of the liver, observed in rats kept on a vitamin B free diet, supplemented with thiamine, riboflavin and vitamin B(6), are indistinguishable from those attributed hitherto to cystine intoxication. Attention is drawn to the rôle of choline as a potential member of the vitamin B(2) complex and, in this connection, to the importance of the ratio cystine/methionine in the diet.
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